Culture & Careers

Ethos

The ethos of Vincerx is composed of our vision, goals, culture, and assets.

Vision

To address the unmet medical needs of our patients with paradigm-shifting therapeutics.

Goals

We aspire to conquer cancer with innovative therapies—translating promising scientific breakthroughs into meaningful therapies for patients with cancer.

Culture

At Vincerx, we are passionate about our work family. We pledged to create an open, aware, and accepting workplace and, by extension, a responsive, innovative, and successful company.  Vincerx is an organization dedicated to delivering training and other resources to help employees, at all levels, feel a sense of belonging and support and achieve their full potential. We are determined to address biases and inequities that may exist in our industry. We believe our focus on diversity and inclusion will enable us to further strengthen our unique and collaborative culture, continue to enhance employee engagement and satisfaction, and drive innovation and improved performance. Our diversity is our strength and sets us apart from many organizations.  We lead with respect, humanity, integrity, and inclusion.

Assets

Our diverse pipeline of targeted medicines consists of:

  • Our small molecule drug program including VIP152, which is a highly selective, clinical-stage positive transcription elongation factor beta/cyclin-dependent kinase 9 (PTEFb/ CDK9) inhibitor and VIP217, an oral PTEFb/CDK9 inhibitor in discovery stage.
  • Our preclinical-stage bioconjugation platform:
    • Our antibody-drug conjugate (ADC) platform includes VIP943 and VIP924, which are next-generation ADC compounds addressing known and novel oncology targets that we believe could deliver an improved safety and efficacy profile than current ADC compounds.
    • Our small molecule drug conjugate (SMDC) platform includes VIP236, which is for solid tumors.

Open positions

Senior Director of Chemical Development

OBJECTIVE / PURPOSE:

Vincerx is seeking an experienced, passionate, and impactful individual to lead the chemical process development, implementation, and management of robust, cost effective, and safe processes for the manufacture of APIs from the research stage, through clinical development and marketing approval.

It is a highly visible role that is integral to the advancement of Vincerx’s growing portfolio of drug candidates and will provide technical oversight for all small molecule drug substance development related activities. The individual will represent chemical development on project teams and collaborate closely with other functions including analytical and formulation development, non-clinical development, quality, regulatory, and supply chain to support program transition from clinical candidate through clinical development phases to NDA and commercialization.

 

PRINCIPAL ROLES / RESPONSIBILITES: 

  • Provide strong scientific leadership to ensure timely and innovative process development and scale-up of drug substance incorporating quality, safety, compliance, cost efficiency, sustainability, and reliability to meet development requirements
  • Direct outsourced chemical development activities in a virtual environment both domestically and internationally
  • Oversees the development and transfer of starting materials, intermediates, and drug substance manufacturing processes to CDMO partners
  • Participate in vendor selection process supporting Drug Substance Manufacturing at CMOs, and the building of a resilient supply chain
  • Oversee contract development and responsible for the technical management of third-party drug substance manufacturers
  • Oversight and direction of GMP production activities at contract CDMOs, including review and approve master batch records, executed batch records, manufacturing deviations, investigations and Change Control
  • Participation in the preparation of technical reports, data summaries and CMC related documents required for various regulatory submissions including IND/IMPD/NDA/BLA/MAA
  • Travel as required to CDMO, CRO and key vendor sites to represent Vincerx for Manufacturing oversight and partnership development purposes.
  • Provide on-site technical support on an as-needed basis to oversee various manufacturing campaign activities. Provide technical expertise to troubleshoot manufacturing process issues
  • Work closely with analytical, bioassay, QC and QA partners to assess product quality and product stability
  • Provide organizational leadership in all areas related to process development
  • Partner with key functions including Quality, Project Management, Clinical Operations, Preclinical, Pharmaceutical Development, Finance and Regulatory Affairs 

 REQUIREMENTS:

  • Subject matter expertise in process chemistry. Experience in late-stage development is preferred, i.e., registration manufacturing and process validation.
  • The candidate must be highly self-motivated, demonstrate exceptional leadership, possess strong experimental skills
  • Excellent written and oral communication abilities
  • Collaborate effectively on multidisciplinary teams and be able to demonstrate flexibility in adapting to change in a fast-paced, dynamic research environment.
  • Remain current with the latest synthetic methodologies
  • Drive innovation, actively apply new concepts to continuously improve process chemistry capabilities and expertise, and be active in the external scientific community via collaboration, publications, and external presentations
  • Ability and track record of successfully working in cross-functional teams to progress projects as a representative of the CMC team in a regulated environment
  • Ability to multitask and be successful in a fast-paced, matrixed work environment
  • Desire to be a part of a highly innovative company aimed at helping patients with serious diseases
  • Must be able to travel frequently when needed.

EDUCATION / TRAINING:   

PhD in synthetic organic chemistry with > 12 years of experience in pharmaceutical research, development, and manufacturing in the life science industry, with > 5-year experience in a leadership role responsible for process development, process characterization, process validation and product life cycle management

 


Director, Business Development

Does the mission to create technology focused drug development partnerships to address the unmet medical needs of cancer patients sound exciting to you? If you strive to leverage your background in drug development, pharmacology, IP, business analytics and industry/scientific networks to deliver on goal, we would like to hear from you.

In this position, you will take a leadership position where your creativity, persistence, enthusiasm, excellent project management and communication skills will be needed to marshal resources across functional areas inside and outside Vincerx Pharma.


Clinical Research Associate

Does the mission to address the unmet medical needs of patients with cancer sound exciting to you? If you strive to leverage your background working closely with a cross-functional team to ensure our clinical trials are being conducted and on the path to success, we would like to hear from you.

In this position, you will be managing the day-to-day clinical operations management of a clinical study along with the Clinical Trial Manager. You will be a core participate in the study management team meetings, managing vendors, clinical monitors, and clinical study sites. This is an integral position that will act as one of the primary contacts between the company and multiple clinical sites and requires excellent communication, written and interpersonal skills and the ability to prioritize and manage multiple tasks.


Open positions

Senior Director of Chemical Development

Director, Business Development

Clinical Research Associate

To learn more about joining the Vincerx Pharma family, please contact us at

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